GHS Ratings
Auto-assignment of GHS Hazard Ratings
The Regulatory Review module (menu #402) has automated GHS ratings available for most of the GHS health hazards (all except organ toxicity). The automatic GHS ratings follow the guidance derived from the UN Purple Book.
In addition to the health hazard ratings, the physical hazard rating for flammable liquids can also be derived from formula data.
The automated GHS Ratings are derived as follows:
GHS Health Hazard Ratings
Acute toxicity, oral: Based on Regulatory Review LD50, Oral.
<= 5 mg/kg: 1
<= 50 mg/kg: 2
<= 300 mg/kg: 3
<= 2000 mg/kg: 4
<= 5000 mg/kg: 5
Acute toxicity, dermal: Based on Regulatory Review LD50, Dermal.
<= 50 mg/kg: 1
<= 200 mg/kg: 2
<= 1000 mg/kg: 3
<= 2000 mg/kg: 4
<= 5000 mg/kg: 5
Acute toxicity, inhalation, Gas: Based on Regulatory Review LC50, inhalation.
<= 0.1 mg/L: 1
<= 0.5 mg/L: 2
<= 2.5 mg/L: 3
<= 5 mg/L: 4
Acute toxicity, inhalation, Dust/Mist: Based on Regulatory Review LC50, inhalation.
<= 0.05 mg/L: 1
<= 0.5 mg/L: 2
<= 1 mg/L: 3
<= 5 mg/L: 4
Skin corrosion:
The following hazmat variables are considered. All units are percent by weight:
Total acids (pH <= 2)
Total bases (pH >= 11.5)
Total non-additive, category 1
Total non-additive, category 2
Total category 1A
Total category 1B
Total category 1C
Total category 1 (= 1A + 1B + 1C) (aka “cat.1”)
Total category 2 (aka “cat.2”)
Total category 3
The total of any category is the total of ingredients AT 1% OR GREATER in the mixture. Ingredients with concentrations of < 1% will be ignored, UNLESS their pH is >= 11.5 or is <= 2.
The decision path is as follows:
If acid, base, or non-additive category 1 are >= 1%, set to 1A.
If category 1A >= 5%, set to 1A.
If category 1A + category 1B >= 5%, set to 1B.
If category 1A + category 1B + category 1C >= 5%, set to 1C.
If non-additive category 2 >= 3%, set to 2.
If cat.1 >= 1% or cat.2 >= 10% or 10*cat.1 + cat.2 >=10%, set to 2.
Set rating to 3 if:
Category 2 >= 1%
Category 3 >= 10%
(Category 1 x 10) + Category 2 >= 1%
(Category 1 x 10) + Category 2 + Category 3 >= 10%
Eye corrosion:
The following hazmat variables are considered. All units are percent by weight:
Total acids (pH <= 2)
Total bases (pH >= 11.5)
Total non-additive, category 1
Total non-additive, category 2
Total category 1 (aka “cat.1”)
Total category 2 (aka “cat.2”)
Total category 2A (aka “cat.2A”)
Total category 2B (aka “cat.2B”)
Total SKIN CORROSION category 1 (= 1A + 1B + 1C)
The total of any category is the total of ingredients AT 1% OR GREATER in the mixture. Ingredients with concentrations of < 1% will be ignored, UNLESS their pH is >= 11.5 or is <= 2.
The decision path is as follows:
If acid, base, or non-additive category 1 are >= 1%, set to 1.
If category 1 >= 3% or SKIN category 1 >= 3%, set to 1.
If category 1 + SKIN category 1 >= 3%, set to 1.
If non-additive category 2 >= 3%, set to 2.
If category 1 >= 1% or SKIN category 1 >= 1%, set to 2.
If category 1 + SKIN category 1 >= 1%, set to 2.
If category 2 + category 2A >= 10%, set to 2.
If cat.1*10 + cat.2 + cat.2A >= 10%, set to 2
If (cat.1 + SKIN cat.1) + cat. 2A + cat. 2B >= 10%, set to 2.
Respiratory sensitizer:
The following hazmat variables are considered. All units are percent by weight:
Total category 1
Total category 1A
Total category 1B
Category 1B is only considered for substances in the mixture at >= 1%.
The decision path is as follows:
If category 1 >= 0.1% or category 1A >= 0.1% or category 1B >= 1%, set to 1.
Skin sensitizer:
The following hazmat variables are considered. All units are percent by weight:
Total category 1
Total category 1A
Total category 1B
Category 1B is only considered for substances in the mixture at >= 1%.
The decision path is as follows:
If category 1 >= 0.1% or category 1A >= 0.1% or category 1B >= 1%, set to 1.
Carcinogen:
All hazmats with a GHS carcinogen rating and present at 0.1% or more will be considered, and the lowest rating reported.
Mutagen:
All hazmats with a GHS mutagen rating and present at 0.1% or more (category 1A, 1B) or 1% or more (category 2) will be considered, and the lowest rating reported.
Reproductive toxin:
All hazmats with a GHS reproductive toxin rating and present at 0.1% or more will be considered, and the lowest rating reported.
Aspiration Hazard:
All hazmats with a GHS aspiration hazard will be added up into AH1 and AH2 categories. If AH1 >= 10% by weight, the mixture is set to 1; else if AH2 >= 10% by weight, the mixture is set to 2.
GHS Physical Hazard Rating
Flammable liquid:
The following formula variables are considered.
Flash point, Celsius (FP)
Lower boiling point, Celsius (BP)
The decision path is as follows:
If FP < 23 and BP <=35, set to 1.
If FP < 23, set to 2.
If FP <= 60, set to 3.
If FP <= 93, set to 4.
Using the GHS Automatic Rating feature
Run 402. Regulatory Review. Load a formula. In the top left panel, locate the checkbox that turns on the automatic GHS ratings:
If the box is not checked, check it, then press TAB to confirm your selection.
The ratings will be filled in using the formula’s hazmat formula as the basis of the calculations.
If manual adjustments are required, you can uncheck the “Auto GHS Ratings” box, make manual changes, and then save. This state will be saved within the regulatory review record for this formula (or raw material, where applicable).
If and when the formula changes, you will be notified on review; you can then re-load the formula, turn the checkbox back on, and see whether the ratings change. Re-loading the formula will restore the original ratings at that point.
Un-checking the box is also necessary when overriding the automatic ratings. You can start with an automatic rating, and then override it at any time. Re-checking the auto GHS rating box will overwrite any manual adjustments if the review is then saved.